Ghazni's Deh Yak district police chief, Habibullah, was killed in a roadside mine blast on Wednesday morning, said the office of the provincial governor in a statement.
The incident happened as Habibullah was on the way to support security forces in a fight with the Taliban in the district and his vehicle struck a roadside mine, it said.
The Taliban has attacked several security checkpoints in the district and clashed with security forces, the statement said.
The Taliban recently increased their attacks on Afghan security forces.
On Tuesday, Mir Zaman, the police commander in Kuz Kunar district in Nangarhar, was killed when a suicide bomber detonated his vehicle in the district market.
Two of the commander's guards were also killed in the incident, said Attaullah Khogyani, the Nangarhar governor's spokesman.
According to Khogyani ten others were wounded in the incident.